周立飞,李兰涛,黄娟,田野,王彬

• 1:南开大学药学院

摘要(Abstract)：

钠-葡萄糖协同转运蛋白2(SGLT2)是最近新发现的糖尿病治疗新靶点,其作用机制是特异性地抑制肾脏对葡萄糖的再吸收,且不依赖于β细胞的功能异常或胰岛素抵抗的程度。其效果也不会随着β细胞功能的衰竭或严重胰岛素抵抗而下降,不会产生传统药物带来的不良反应,是糖尿病治疗的新途径。本文介绍SGLT2在调节体内糖平衡中的作用,总结SGLT2抑制剂在2型糖尿病治疗方面的最新进展,并对已报道的抑制剂化学结构进行总结。

关键词(KeyWords)： 2型糖尿病;SGLT2;抑制剂;构效关系

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(20902050);; 天津市自然科学基金项目(09JCYBJC09200)

作者(Author): 周立飞,李兰涛,黄娟,田野,王彬

DOI: 10.14142/j.cnki.cn21-1313/r.2011.04.007

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