3,5-二亚苄基哌啶-4-酮类化合物的合成及其体外抗肿瘤活性Synthesis of 3,5-dibenzylidenepiperidin-4-one analogs and their antitumor activities in vitro
刘洋,许建华,李娜,张南文,许娇红
摘要(Abstract)：
目的合成3,5-二亚苄基哌啶-4-酮类化合物,并对其体外抗肿瘤活性进行初步评价。方法以芳香醛、4-哌啶酮为原料,通过Claisen-Schmidt缩合制备目标化合物。采用MTT法测试目标化合物对人慢性粒细胞白血病急变细胞株K562增殖的抑制活性,考察部分化合物对多种肿瘤细胞株的抑制活性。结果与结论合成了7个未见报道的3,5-二亚苄基哌啶-4-酮类化合物,其结构经1H-NMR和MS谱确证;5个目标化合物的体外抗肿瘤活性明显强于姜黄素。
关键词(KeyWords)： 姜黄素;姜黄素类似物;3,5-二亚苄基哌啶-4-酮;抗肿瘤活性
基金项目(Foundation): 福建省产业技术开发项目([2008]391);; 福建省科技厅资助省属高校项目(2007F5055)
作者(Author): 刘洋,许建华,李娜,张南文,许娇红
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