石旭柳,闫建昆,丁丽琴,邱峰

• 1:天津中医药大学中药学院
• 2:河北农业大学理工系

摘要(Abstract)：

目的研究植物杜仲(Eucommia ulmoides Oliver)叶中的化学成分。方法综合运用硅胶柱色谱、反相硅胶柱色谱和Sephadex LH-20凝胶柱色谱以及制备型高效液相色谱等方法进行系统分离,根据化合物的理化性质及其波谱数据确定化合物的结构。结果从杜仲叶80%(体积分数)乙醇提取物中分离得到了12个倍半萜和降碳倍半萜类化合物,分别鉴定为(3S,5R,6R,7E,9R)-megastigman-7-ene-3,5,6,9-tetrol(1)、(3S,5R,6R,7E,9S)-megastigman-7-ene-3,5,6,9-tetrol(2)、(3R,5R,6R,7E)-3,5,6-trihydroxy-7-megastigmen-9-one(3)、(3S,5R,6R,7E)-3,5,6-trihydroxy-7-megastigmen-9-one(4)、cis-3,4-dihydroxy-β-ionon(5)、3-hydroxy-5,6-epoxy-β-ionol(6)、(S)-3-hydroxy-8-ionone(7)、(6R,9S)-9,10-dihydroxy-4-megastigmen-3-one(8)、cucumegastigmane I(9)、(-)-菜豆酸(10)、(-)-2E-菜豆酸(11)、蚱蜢酮(12)。结论化合物11为新化合物,2～10和12为首次从杜仲中分离得到。

关键词(KeyWords)： 杜仲叶;化学成分;倍半萜;降碳倍半萜;结构鉴定

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金重点项目(81430095);; 河北省高等学校科学技术研究重点项目(ZD2020119);; 河北农业大学师生协同创新项目(bhxt201810)

作者(Author): 石旭柳,闫建昆,丁丽琴,邱峰

DOI: 10.14142/j.cnki.cn21-1313/r.2021.01.002

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